As a seasoned researcher in cognitive health, my experience suggests that nootropics for anxiety are an often overlooked aspect of mental well-being. When discussing anxiety, the term 'nootropic' might not be the first solution that comes to mind. However, these brain supplements for anxiety have shown notable benefits in several scientific studies (Gasperi et al., 2019).

Anxiety, extending beyond a fleeting sense of worry or fear, can be a crippling condition, impacting multiple facets of life. It encompasses more than just social anxiety or sporadic panic attacks - it's a persistent challenge affecting millions across the globe. Despite its high prevalence, effective management strategies can sometimes be limited or accompanied by undesired side effects. This is where nootropics come into the picture as a promising avenue.

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Understanding Anxiety and Its Impact on  Brain Function

Anxiety disorders, which include generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobias, rank among the most common mental health disorders (Bandelow and Michaelis, 2015). Each form of anxiety presents a unique symptomatology, but all significantly affect an individual's quality of life.

Understanding how anxiety affects brain function is vital in the journey to manage it effectively. Anxiety disorders are not just a consequence of external circumstances or personality traits; they are intimately tied to brain chemistry. Recent research demonstrates that anxiety can induce changes in certain brain areas, including the amygdala and the hippocampus (Martin et al., 2009).

Anxiety causes brain chemistry

The amygdala is often dubbed the 'fear center' of the brain, playing a pivotal role in processing emotional responses, including fear and anxiety. The hippocampus, conversely, helps regulate emotional responses through its connection to the amygdala and is essential for memory formation. When these regions experience chronic exposure to the stress hormone cortisol during extended periods of anxiety, it can result in functional and structural changes, thereby exacerbating anxiety symptoms.

Here's where anxiolytic nootropics step in. These brain supplements can influence cognitive health and, specifically, aim to restore the balance of chemicals and neurotransmitters in the brain. They play a key role in mood regulation and managing depression and anxiety symptoms.

Do note, however, while nootropics may provide support in managing anxiety, they should not replace professional medical advice or treatment.

In the next section, we'll delve deeper into the world of nootropics, understanding their potential benefits, how they function, and how they contribute to managing anxiety.

What are Nootropics and How Do They Work?

Nootropics, often referred to as "smart drugs" or cognitive enhancers, are substances known to improve cognitive functions. These functions include memory, creativity, and even motivation in healthy individuals. But beyond these, there are specific nootropics for anxiety that have shown promising effects in reducing symptoms and promoting a state of calm.

Nootropics can be natural or synthetic. Natural nootropics often consist of herbs, amino acids, and other components found in nature. On the other hand, synthetic nootropics are man-made substances designed to deliver more potent effects. It's important to understand that nootropics work differently for everyone, given our unique brain chemistry and physiological factors.

Anxiety nootropics

These cognitive enhancers work by modulating various neurotransmitters and brain pathways. Anxiolytic nootropics, or anxiety-reducing nootropics, primarily work by influencing the levels or actions of neurotransmitters like serotonin, dopamine, and gamma-aminobutyric acid (GABA). These neurotransmitters play a significant role in mood regulation, stress response, and feelings of well-being.

Anxiety often arises from an imbalance in these neurotransmitters. Hence, certain nootropics for anxiety can help restore balance and promote calmness. For instance, some anxiolytics boost the production or effect of GABA, a neurotransmitter that slows down brain activity, resulting in relaxation and a reduction in feelings of fear or anxiety.

Nootropics for anxiety can thus have a two-pronged effect. They not only help alleviate immediate symptoms of anxiety but can also contribute to long-term brain health, potentially reducing the likelihood of severe anxiety or panic attacks.

Top Nootropics For Anxiety & Stress 2023

Navigating the world of nootropics for anxiety can be a challenge given the wide array of options available. To make the selection easier, here are some of the best nootropics for anxiety, based on user experiences, scientific research, and their overall anxiety-reducing potential.

The most effective nootropics for stress and anxiety according to the latest clinical evidence are:

  1. Ashwagandha

  2. L-Theanine

  3. GABA

  4. Panax Ginseng

  5. Phenibut

  6. Noopept

  7. Rhodiola rosea

Below is a more detailed overview of each anti-anxiety nootropic, what it does and how it works. I will then recommend my top anxiety nootropic stack overall.


Ashwagandha, scientifically known as Withania somnifera, is a revered herb in Ayurvedic medicine. It's considered an adaptogen, a unique class of plants known to help your body manage stress more efficiently. Ashwagandha is known for its ability to reduce cortisol levels in the body. Cortisol, the body's primary stress hormone, rises in response to stress and low blood-glucose concentration. By reducing cortisol levels, Ashwagandha can help alleviate symptoms of stress and anxiety, leading to improved mental well-being and mood.


L-Theanine is a naturally occurring amino acid, primarily found in tea leaves, that is known to promote relaxation without inducing drowsiness. It's an excellent choice for individuals dealing with anxiety who still need to stay alert and focused during the day. The mechanism behind this involves its ability to cross the blood-brain barrier and influence brain chemistry. L-Theanine is believed to increase levels of GABA, along with other calming brain chemicals like serotonin and dopamine, offering anxiolytic benefits.

Theanine anxiety nootropic


Gamma-aminobutyric acid (GABA) is a key neurotransmitter naturally produced in our brains. It plays a critical role in reducing the activity of neurons in the brain and central nervous system, which in turn promotes relaxation, reduces stress, enhances sleep, and lowers anxiety levels. When you're using GABA as a nootropic supplement, it functions as a direct messenger to the brain, promoting a state of calm and reducing feelings of fear and anxiety.

Panax Ginseng

Panax Ginseng is a potent herb used extensively in traditional Chinese medicine. It's recognized for its ability to combat fatigue, a common companion of chronic anxiety, and improve stress response. Ginsenosides, the active compounds in Panax Ginseng, are believed to act on the hypothalamic-pituitary-adrenal axis, the body's central stress response system, helping to regulate how the body responds to stress factors. It thereby helps in enhancing overall mood and mental function, making it an effective nootropic for anxiety.


Phenibut is a synthetic anxiolytic compound developed in Russia. It's structurally similar to GABA and has the ability to cross the blood-brain barrier, unlike GABA supplements. Once in the brain, it mimics the action of natural GABA, binding to GABA receptors and slowing down excitatory neurotransmission. This promotes a sense of calm, reduces anxiety symptoms, and improves mood. It's worth noting, however, that due to its potency, Phenibut should be used under professional supervision to prevent overuse or potential dependency.

Noopept anxiety effects


Noopept is a potent, synthetic nootropic that is known for its ability to enhance cognitive function. However, it's not just cognitive enhancement where Noopept shines - it has also been noted for its anxiolytic or anti-anxiety properties. Noopept functions by mimicking the action of the neurotransmitter cycloprolylglycine in the brain, which is known to have a positive effect on mood and anxiety levels.

Additionally, Noopept stimulates the expression of two important cognitive factors in the brain: Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). These factors play a significant role in brain health, learning, memory, and neural plasticity. As a result, Noopept not only helps reduce feelings of anxiety but may also contribute to overall brain health and cognitive function. However, due to its potency, Noopept should be used responsibly and preferably under professional supervision.

Rhodiola Rosea

Rhodiola Rosea, a plant native to the Arctic regions of Europe and Asia, has been used in traditional medicine for centuries, particularly in Russia and Scandinavian countries. This herb is known for its adaptogenic properties, meaning it helps the body effectively deal with stress.

The active compounds in Rhodiola, such as rosavin and salidroside, help to enhance the body's stress response system. Specifically, these compounds influence the balance of serotonin and norepinephrine in the brain, neurotransmitters directly linked to mood and stress response. Rhodiola Rosea thereby promotes a feeling of calmness, helps combat fatigue, and supports mental performance, making it a beneficial nootropic for managing anxiety.

As always, while these nootropics for anxiety offer promising benefits, they are not a standalone solution for anxiety disorders or chronic stress. They should be used as part of a holistic approach to managing anxiety, which may include other lifestyle modifications like regular exercise, a balanced diet, mindfulness practices, and professional medical advice. Always consult with a healthcare professional before starting any new supplement regimen.

The Best OTC Anxiety Nootropic: Xanapril

If you're searching for the most effective over-the-counter nootropic for anxiety, look no further than Xanapril. This innovative brain supplement has been expertly formulated to not only manage anxiety and stress but also enhance cognitive performance during periods of high mental strain.

Xanapril anxiety supplement

One of Xanapril's primary selling points is its all-encompassing blend of clinically-backed nootropics. It combines Ashwagandha, Theanine, GABA, Korean Ginseng, and Rhodiola rosea into a single stack, delivering optimal dosages of each. This combination ensures rapid suppression of anxiety levels and effective combat against stress symptoms.

In addition to these potent anxiolytic effects, Xanapril also works to enhance cognitive performance. During times of peak mental strain and stress, this formula keeps your cognitive abilities sharp, enabling better focus, decision-making, and overall mental agility.

The benefits of Xanapril include:

  1. Fast-acting anxiety relief: By synergizing the benefits of five potent nootropics, Xanapril offers a rapid and potent reduction in anxiety levels.

  2. Effective stress management: Xanapril helps combat both physical and mental symptoms of stress, promoting a calmer, more balanced mood.

  3. Enhanced cognitive performance: Despite high-stress situations, Xanapril ensures your cognitive abilities remain sharp, enabling better focus, problem-solving, and decision-making.

  4. Comprehensive formula: No need for separate supplements. Xanapril combines the best nootropics for anxiety into one convenient stack, making your wellness routine simpler and more efficient.

  5. Safe and non-addictive: As an over-the-counter supplement, Xanapril is designed for safe, daily use without the risk of dependency.

Xanapril brings together the best nootropics for anxiety into one powerful stack, delivering not only anxiety relief but also cognitive enhancement during high-stress periods. With Xanapril, you can gain control over your anxiety and stress, while maintaining your mental sharpness, focus, and productivity. As always, consult with a healthcare professional before starting any new supplement regimen.

How to Choose the Right Nootropic and Determine the Right Dosage

Choosing the right nootropic for anxiety starts with understanding your unique needs and health profile. Consider factors such as your specific symptoms, the severity of your anxiety, any co-occurring conditions, your lifestyle, and any other medications or supplements you're currently taking.

Once you've identified a nootropic that seems well-suited to your needs, it's time to consider the dosage. Dosage can vary widely depending on the specific nootropic, your individual needs, and how you respond to the supplement. For instance, a standard dosage of L-Theanine ranges from 100-200mg per day, while a common dose of Phenibut might be significantly less due to its potency.

Anxiety stress nootropic dosing

Start with the lowest recommended dose, and monitor your response carefully. If you're finding benefit without experiencing side effects, you might consider gradually increasing the dose, but always do this under the supervision of a healthcare provider.

Additionally, bear in mind that most nootropics for anxiety need to be taken consistently for several weeks before their full benefits can be felt. Patience is key here.

Finally, when choosing a nootropic supplement, consider the brand's reputation and whether the product is third-party tested. High-quality supplements will provide transparency around ingredients and manufacturing processes, ensuring you're getting a safe and effective product.

Can Nootropics Help With Overthinking & Intrusive Thoughts?

Overthinking and intrusive thoughts can be disruptive and distressing, often leading to anxiety and stress. Nootropics, also known as "smart drugs" or cognitive enhancers, have the potential to mitigate some of these mental obstacles by influencing the way the brain functions.

Research suggests that certain nootropics can help regulate neurotransmitter activity, which is closely linked to our thinking processes. For instance, nootropics such as L-Theanine and Ashwagandha can increase levels of calming neurotransmitters like GABA, serotonin, and dopamine. This can create a sense of calm and balance, which might help reduce the frequency of intrusive thoughts and the tendency to overthink.

Noopept and Phenibut, on the other hand, have been noted for their potential to enhance cognitive function and reduce anxiety. By improving cognitive efficiency, they can help in managing thought processes better, potentially curtailing the tendency to overthink.

However, while these nootropics may help in alleviating symptoms of overthinking and intrusive thoughts, they are not a magic bullet. They should be used as part of a comprehensive strategy to manage these issues, which could also include cognitive-behavioral therapy, mindfulness techniques, and regular exercise. Always consult with a healthcare professional before starting any new supplement regimen.

Can Nootropics Help With Panic Attacks

Panic attacks can be an overwhelming experience, characterized by sudden episodes of intense fear or anxiety. They are often accompanied by physical symptoms such as racing heart, shortness of breath, or nausea. Some nootropics may help manage the frequency and severity of panic attacks, primarily by addressing underlying anxiety and stress response.

Certain nootropics, like L-Theanine and Ashwagandha, work by increasing levels of calming neurotransmitters such as GABA, serotonin, and dopamine in the brain. These chemicals can help reduce the general anxiety levels that often precede panic attacks.

Phenibut, a synthetic derivative of GABA, can also be beneficial due to its potent anxiolytic effects. It's known to slow down overactive brain signaling that could trigger panic episodes. However, due to its potency, it must be used with caution and under the supervision of a healthcare professional.

While nootropics may help with the management of panic attacks, they are not a definitive solution. They should be used as part of a broader therapeutic approach that might include psychotherapy, mindfulness practices, lifestyle changes, and, if necessary, conventional medication. As always, consult with a healthcare professional before beginning any new supplement regimen for panic attacks.

The Significance of Lifestyle Modifications in Anxiety Management

When dealing with anxiety, it's essential to recognize the significance of lifestyle modifications in managing anxious thoughts and nervous feelings. While brain supplements, including nootropics for anxiety, can provide a useful boost, they should be viewed as part of a broader approach that includes key lifestyle changes.

Firstly, it's vital to maintain a balanced diet rich in nutrients that support brain health and mood. Certain nutrients, like omega-3 fatty acids, B-vitamins, and magnesium, are known to play a crucial role in neurotransmitter function and stress response. Incorporating these nutrients into your diet can help manage anxious feelings and serve as natural brain supplements.

Regular physical exercise is another powerful tool for anxiety management. Exercise triggers the release of endorphins, often termed "feel-good hormones," which can counteract feelings of stress and promote a sense of well-being. Even simple activities like a brisk walk or yoga can have a significant impact on reducing anxiety levels.

Sleep hygiene cannot be overstated in its importance. Lack of sleep or poor-quality sleep can heighten feelings of nervousness and anxiety. Prioritizing good sleep habits, such as maintaining a regular sleep schedule and creating a restful environment, can help manage anxiety symptoms.

Mindfulness practices such as meditation and deep-breathing exercises can also be helpful. These practices allow us to stay focused on the present moment rather than getting caught up in stressful thoughts about the past or future. Over time, these techniques can train the brain to respond more calmly to stressful situations.

Lastly, maintaining a strong support network and seeking professional help when needed is essential. Speaking to a therapist or counselor can provide valuable tools and strategies to cope with anxiety and manage stressful situations more effectively.

In conclusion, while brain supplements like anxiolytic nootropics can be beneficial, it's the synergy of these supplements with lifestyle modifications that creates a more holistic, effective approach to anxiety management. Always consult with a healthcare professional before making any significant changes to your lifestyle or supplement regimen.

Conclusion: Can Nootropics Help with Anxiety?

In conclusion, nootropics can be a valuable part of a holistic approach to managing anxiety. While they are not a cure-all, they can help to enhance mood, reduce stress response, and improve overall cognitive function.

The key is to approach nootropics with an informed mindset, understanding what they can and can't do, and always prioritizing safety. Remember, while nootropics for anxiety offer promising benefits, they are not a standalone solution for anxiety disorders or chronic stress.

Xanapril best nootropic anxiety

Xanapril offers an exceptional blend of clinically-backed nootropics, combining Ashwagandha, Theanine, GABA, Korean Ginseng, and Rhodiola rosea into one potent formula. This synergy ensures rapid suppression of anxiety and effective stress management, providing users with fast-acting relief. More than just an anxiety suppressant, Xanapril also enhances cognitive performance during periods of high mental stress, keeping focus, decision-making, and mental agility sharp. 

By amalgamating the best nootropics for anxiety into one comprehensive, safe, and non-addictive stack, Xanapril simplifies your wellness routine while providing robust protection against anxiety and stress.

Always consult with a healthcare professional before starting any new supplement regimen. With the right approach, the best nootropics for anxiety can help you navigate life with a bit more ease, focus, and calm.

Nootropics, also known as "smart drugs'' or cognitive enhancers, have gained popularity

Brain fog, a term that encapsulates the frustrating feeling of sluggish thinking,

About the Author Chris Fraighten

Chris Fraighten is a leading biomedical researcher and currently the lead author of the Epimodels blog. He holds qualifications in chemistry, biology and is highly experienced in the fields of quantitative modelling and epidemiology. He brings this wealth of knowledge and experience to the Epimodels blog to bring you insightful, informative and interesting content on the latest advances in the space.