In today's fast-paced world, anxiety has become an all too common ailment, affecting individuals of all ages and walks of life. As we strive to manage our mental health, natural supplements have emerged as a popular solution, providing holistic alternatives to traditional medication. 

One such supplement is Lion's Mane, a medicinal mushroom with a long history of use in traditional Chinese medicine. Recently, it's gained considerable attention for its potential benefits in supporting mental health, notably its efficacy in managing anxiety. But is Lion's Mane really good for anxiety? 

In this article, we delve into the scientific evidence behind Lion's Mane and its role in anxiety management, exploring how it might serve as a potential ally in your mental health toolkit.

See The Best Nootropics For Anxiety

There are hundreds of supplements on the market today promising to help you stay calm and focused. But in reality, only a small number can be said to be effective at reducing stress and anxiety. We are constantly reviewing new nootropics and anxiolytics to find the ones that really work. Check out our current ranking to see the top choices on the market today.

Lion's Mane and Anxiety: What Does the Research Say?

While most research on Lion's Mane has focused on its potential cognitive benefits, there have been a few studies that examined its effects on anxiety. A 2010 study by Nagano et al. found that women with a variety of menopausal symptoms, including anxiety, experienced significant improvements in their psychological well-being after taking Lion's Mane extract for four weeks (Nagano et al., 2010). Although this study specifically targeted menopausal women, it provides preliminary evidence that Lion's Mane may have anxiolytic properties.

Another study conducted on mice found that Lion's Mane extract reduced anxiety-like behavior, suggesting that it could have a similar effect on humans (Rahman et al., 2018). However, more research is needed to confirm these findings and to better understand the mechanisms by which Lion's Mane may alleviate anxiety.

Lion's Mane Mechanism of Action for Anxiety

Lion's Mane's potential anxiolytic effects can be attributed to its unique bioactive compounds, which are believed to play a role in influencing various pathways related to anxiety. Although the exact mechanisms are not yet fully understood, some key aspects of Lion's Mane's actions have been identified:

  1. Neurogenesis: Lion's Mane contains compounds called hericenones and erinacines, which have been shown to stimulate nerve growth factor (NGF) production in the brain (Lai et al., 2013). NGF is essential for the growth, maintenance, and survival of neurons, and higher levels of NGF can help promote neurogenesis, the process of creating new neurons. Neurogenesis has been linked to a reduction in anxiety and improved mood (Egeland et al., 2017).

  2. Neuroprotection: Lion's Mane's bioactive compounds also have neuroprotective properties, meaning they can help protect the brain from damage caused by oxidative stress, inflammation, and other factors (Zhang et al., 2016). By preserving the integrity of neurons and brain structures, Lion's Mane may help maintain a healthy brain environment and potentially reduce anxiety.

  3. Anti-inflammatory effects: Chronic inflammation has been associated with the development of anxiety and mood disorders. Lion's Mane exhibits anti-inflammatory properties, which could help reduce inflammation in the brain and contribute to anxiety relief (He et al., 2017).

  4. Modulation of neurotransmitters: Lion's Mane may have an indirect impact on neurotransmitter levels, such as serotonin and dopamine, which are key players in regulating mood and anxiety (Wong et al., 2012). By influencing the production and release of these neurotransmitters, Lion's Mane may help alleviate anxiety symptoms.

While more research is needed to fully understand the mechanisms underlying Lion's Mane's potential anxiolytic effects, these factors suggest that it may have a positive impact on anxiety through its neuroprotective, neuroregenerative, and anti-inflammatory properties.

Lion's mane for anxiety

More Effective Nootropics for Anxiety

While Lion's Mane shows some promise for anxiety relief, there are other nootropics with more substantial research supporting their anxiolytic properties. These include Rhodiola rosea, Ashwagandha, L-theanine, and Panax Ginseng.

Rhodiola rosea

Rhodiola rosea is an adaptogenic herb known for its stress-reducing and mood-enhancing properties. A study by Cropley et al. found that Rhodiola rosea significantly reduced anxiety, stress, anger, confusion, and depression in participants with life-stress symptoms (Cropley et al., 2015). Rhodiola rosea may be more effective for anxiety relief than Lion's Mane due to its well-documented stress-reducing effects.


Ashwagandha is another adaptogenic herb with well-established anxiolytic properties. A systematic review by Pratte et al. found strong evidence supporting the use of Ashwagandha for anxiety and stress relief (Pratte et al., 2014). Ashwagandha has been used for centuries in Ayurvedic medicine to promote relaxation and mental well-being.

Ashwagandha nootropic for anxiety


L-Theanine is an amino acid found in green tea that has been shown to have a calming effect on the brain. A study by Higashiyama et al. demonstrated that L-Theanine significantly reduced anxiety in participants exposed to a stress-inducing task (Higashiyama et al., 2011). L-Theanine may be a suitable option for those seeking a natural anxiolytic supplement.

Panax Ginseng

Panax Ginseng is another adaptogenic herb with potential anxiolytic properties. A study by Lee et al. found that Panax Ginseng reduced anxiety and improved cognitive performance in participants with chronic fatigue syndrome (Lee et al., 2013).

While Panax Ginseng's primary focus is on improving cognitive function and reducing fatigue, its potential anxiolytic effects make it an interesting option for those seeking to alleviate anxiety.

Top Nootropics For Anxiety


#1 Rated


Xanapril is a cutting-edge natural supplement designed to dramatically decrease stress and anxiety levels without producing any kind of drowsiness or cognitive impairment in users. In fact, Xanapril has been designed in such a way as to treat stress and anxiety in multiple different ways while actually enhancing cognitive performance and improving mood. 

Nooceptin top rated nootropic stack

#2 Rated


Nooceptin is an all-in-one nootropic designed to provide total cognitive enhancement on a daily basis. The benefits of taking Nooceptin include sharper focus, better working memory function, faster processing speeds and reduced stress & anxiety. Nooceptin also supports brian cell health and maintenance, making it ideal for use alongside stimulants. 


#3 Rated


Vyvamind is a neurostimulant and study aid specifically designed to help you stay focused, motivated and productive throughout your working day. While it has not been designed to replace ADHD medication, many users find that it replicates the benefits of drugs such as Adderall without the negative side effects.

Conclusion: Is Lion's Mane good for anxiety and stress?

Lion's Mane may have some potential for alleviating anxiety, but the current research is limited and primarily focused on its cognitive-enhancing properties. For those seeking a more established and researched anxiolytic supplement, Rhodiola rosea, Ashwagandha, L-Theanine, or Panax Ginseng may be more effective choices.

It is essential to consult with a healthcare professional before adding any supplement to your regimen, especially if you are currently taking medications or have a pre-existing medical condition. Anxiety is a complex condition, and while nootropics may provide some relief, it is crucial to address the underlying causes and consider a comprehensive approach that includes therapy, lifestyle changes, and possibly medication.

In summary, Lion's Mane has shown some promise in reducing anxiety, but more research is needed to confirm its effectiveness. Other nootropics like Rhodiola rosea, Ashwagandha, L-Theanine, and Panax Ginseng have more substantial evidence supporting their anxiolytic properties and may be better options for those seeking natural anxiety relief.

Lion's Mane (Hericium erinaceus) is a mushroom known for its potential cognitive-enhancing

In today's fast-paced world, anxiety has become an all too common ailment,

About the Author Chris Fraighten

Chris Fraighten is a leading biomedical researcher and currently the lead author of the Epimodels blog. He holds qualifications in chemistry, biology and is highly experienced in the fields of quantitative modelling and epidemiology. He brings this wealth of knowledge and experience to the Epimodels blog to bring you insightful, informative and interesting content on the latest advances in the space.