Phenibut, a central nervous system depressant and anxiolytic, has gained popularity for its potential to reduce anxiety, improve sleep, and promote cognitive function.

Despite its benefits, the safety of phenibut remains a concern, as its use is associated with various side effects and health risks. 

In this comprehensive article, we will discuss the immediate and long-term side effects of phenibut, the risks of daily or heavy use, ways to mitigate these risks, and potential safer alternatives.

See The Best Nootropics For Anxiety

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Immediate Side Effects of Phenibut

Phenibut use can lead to several immediate side effects, which can range from mild to severe depending on factors such as dosage, individual physiology, and drug interactions. Some common immediate side effects include:

  1. Drowsiness: Phenibut is known for its sedative properties and can cause drowsiness, particularly at higher doses (Lapin, 2001).

  2. Nausea and gastrointestinal issues: Some users may experience nausea, vomiting, or stomach cramps after taking phenibut (Owen et al., 2016).

  3. Headaches: Phenibut can cause headaches in some individuals, which may be related to changes in cerebral blood flow or neurotransmitter levels (Lapin, 2001).

  4. Allergic reactions: Although rare, some users may experience allergic reactions to phenibut, such as skin rashes, itching, or difficulty breathing (Owen et al., 2016).

Phenibut side effects

Long-Term Side Effects of Phenibut

Research on the long-term side effects of phenibut is limited, but some potential risks have been identified:

  1. Tolerance and dependence: Prolonged use of phenibut can lead to tolerance and dependence, increasing the risk of withdrawal symptoms and potentially causing lasting effects on brain function (Samokhvalov et al., 2013).

  2. Cognitive impairment: Chronic phenibut use may lead to cognitive deficits, including memory problems and difficulties in concentration (Lapin, 2001).

  3. Depression: Long-term phenibut use may contribute to the development of depressive symptoms (Samokhvalov et al., 2013).

  4. Physical health issues: Chronic use of phenibut may cause liver damage, gastrointestinal issues, and other physical health problems (Owen et al., 2016).

Risks of Daily or Heavy Phenibut Use

Daily or heavy phenibut use can significantly increase the risk of side effects and health issues, including:

  1. Increased risk of withdrawal symptoms: Daily or heavy phenibut use increases the likelihood of developing withdrawal symptoms, which can range from rebound anxiety and insomnia to severe cases of psychosis (Samokhvalov et al., 2013).

  2. Higher risk of overdose: Taking high doses of phenibut or using it frequently can increase the risk of overdose, which may result in severe side effects such as respiratory depression, seizures, or even death (Owen et al., 2016).

  3. Impaired cognitive function: Heavy phenibut use may negatively impact cognitive function, leading to difficulties in memory, concentration, and decision-making (Lapin, 2001).

Ways to Mitigate the Side Effect Risks of Phenibut

There are several strategies to minimize the risks associated with phenibut use:

  1. Follow recommended dosages: Adhering to recommended dosages can help reduce the likelihood of side effects and prevent tolerance or dependence. Dosages typically range from 250 to 1000 mg per day, depending on the intended use and individual factors (Lapin, 2001). 2. Cycle phenibut use: Taking regular breaks from phenibut can help prevent tolerance and dependence, reducing the risk of withdrawal symptoms. For example, using phenibut for no more than two consecutive days followed by a break of at least three days may help maintain its effectiveness and minimize risks (Samokhvalov et al., 2013).

  1. Monitor for side effects: Regularly assess your response to phenibut and be aware of any side effects or changes in your mental or physical health. If you notice any adverse reactions, consult a healthcare professional immediately.

  2. Avoid combining with other substances: Combining phenibut with other central nervous system depressants or substances that may interact with it can increase the risk of side effects and adverse reactions (Owen et al., 2016). Consult a healthcare professional before combining phenibut with other medications or supplements.

  3. Consult a healthcare professional: Always consult with a healthcare professional before starting, stopping, or modifying your phenibut use to ensure a safe and effective treatment plan.

Safer, Natural Alternatives to Phenibut

If you're concerned about the potential side effects and health risks associated with phenibut, consider exploring safer, natural alternatives for anxiety relief and cognitive enhancement:

  1. L-Theanine: An amino acid found in green tea, L-theanine promotes relaxation and stress relief without causing drowsiness (Hidese et al., 2019). It has been shown to reduce anxiety and improve cognitive function in some studies.
  2. Ashwagandha: An adaptogenic herb, ashwagandha has been traditionally used to reduce stress, anxiety, and improve sleep quality (Chandrasekhar et al., 2012). Its anxiolytic effects have been supported by various clinical trials.
  3. Bacopa Monnieri: Bacopa Monnieri is an Ayurvedic herb known for its potential to improve memory, focus, and reduce anxiety (Calabrese et al., 2008). Its cognitive-enhancing properties have been demonstrated in several clinical trials.
  4. Valerian root: Valerian root has been used for centuries as a natural remedy for anxiety and sleep disorders (Houghton, 1999). It may provide a safer alternative to phenibut for individuals seeking relief from anxiety or insomnia.
  5. Passionflower: Passionflower has been traditionally used as a natural remedy for anxiety and sleep disorders (Akhondzadeh et al., 2001). Some clinical trials have demonstrated its efficacy in reducing anxiety and improving sleep quality.
  6. Magnesium: A vital mineral for numerous physiological functions, including nerve transmission and the regulation of mood, magnesium has been found to have a calming effect on the nervous system. Deficiency in magnesium has been linked to heightened levels of anxiety (Boyle et al., 2017). Supplementing with magnesium could potentially aid in reducing stress and enhancing overall mood.
  7. GABA: Short for gamma-aminobutyric acid, GABA is a neurotransmitter that plays a key role in managing stress, anxiety, and mood. GABA's primary function is to reduce neuronal excitability, thus promoting calmness and relaxation. Natural GABA supplements could be a safer alternative to Phenibut for individuals looking to manage their anxiety levels (Boonstra et al., 2015).
  8. Rhodiola Rosea: Renowned for its adaptogenic properties, Rhodiola Rosea has been used traditionally to combat fatigue and stress. Some studies have suggested that Rhodiola may help to improve mood and reduce stress-related fatigue (Cropley et al., 2015). This makes it a potentially beneficial alternative to Phenibut for individuals seeking natural stress relief.
  9. Tyrosine: As an amino acid, Tyrosine is a precursor to crucial neurotransmitters like dopamine, norepinephrine, and adrenaline. It is known to enhance cognitive performance, particularly in stressful situations by boosting the brain's dopamine levels (Jongkees et al., 2015). This could provide a more balanced and potentially safer alternative to Phenibut, enhancing cognition while also mitigating stress.

As is always the case with nootropics - especially when it comes to mitigating anxiety and stress - optimal results are obtained when you take several natural substances together at the same time in doses that are calibrated to your body and brain.

If you are looking for a safer, natural substitute for Phenibut owing to the many side effect risks associated with the drug (to say nothing of the legality of using it off-label without a prescription in some jurisdictions), we strongly recommend using a comprehensive anti-anxiety stack. This is always going to produce better results than using any one substance in isolation, and is the only practical way to mimmick the effects pf pharmaceutical drugs.

Phenibut health risks

Top Phenibut Alternatives

Xanapril

#1 Rated

Xanapril

Xanapril is a cutting-edge natural supplement designed to dramatically decrease stress and anxiety levels without producing any kind of drowsiness or cognitive impairment in users. In fact, Xanapril has been designed in such a way as to treat stress and anxiety in multiple different ways while actually enhancing cognitive performance and improving mood. 

Nooceptin top rated nootropic stack

#2nd Rated

Nooceptin

Nooceptin is an all-in-one nootropic designed to provide total cognitive enhancement on a daily basis. The benefits of taking Nooceptin include sharper focus, better working memory function, faster processing speeds and reduced stress & anxiety. Nooceptin also supports brian cell health, maintenance and development, making it ideal for long-term, daily use. This is the most powerful full-spectrum nootropic you can buy OTC.

Vyvamind

#1st Rated

Vyvamind

Vyvamind is perfect for those of you looking for an alternative to synthetic smart drugs which don't cause anxiety. While compounds like Modafinil, Vyvanse and Oxiracetam are all unarguably effective, they are all prone to causing quite serious side effects, including acute anxiety. Vyvamind was specifically developed to provide the same increases in focus, mental clarity and motivation as prescription smart drugs, but without the same side effects or long-term health risks. 

Phenibut Dangers FAQ

How toxic is phenibut?

Phenibut toxicity depends on dosage, frequency, and individual factors. Overdose risks increase with high doses or frequent use, leading to side effects like respiratory depression, seizures, or even death. Always follow recommended dosages and consult a healthcare professional to minimize toxicity risks.

What does phenibut do to the brain?

Phenibut acts on GABA receptors in the brain, reducing anxiety, promoting relaxation, and improving sleep. However, prolonged use may cause tolerance, dependence, cognitive impairment, and other long-term effects on brain function.

Is it okay to take phenibut?

Phenibut can provide anxiety relief and cognitive enhancement, but it's essential to consider its potential side effects and health risks. Consult a healthcare professional before using phenibut, follow recommended dosages, and explore safer alternatives like L-theanine or ashwagandha.

Can you hallucinate on phenibut?

Hallucinations are not a common side effect of phenibut. However, high doses, misuse, or combining phenibut with other substances can increase the risk of adverse effects, including hallucinations or other unusual experiences.

Can phenibut cause psychosis?

Phenibut use, especially heavy or prolonged use, can increase the risk of developing withdrawal symptoms, which may include severe cases of psychosis. Always adhere to recommended dosages and consult a healthcare professional to minimize potential risks.

Conclusion: Is Phenibut safe to take?

While phenibut offers potential benefits for anxiety relief and cognitive enhancement, its safety remains a concern due to various immediate and long-term side effects and health risks. Daily or heavy phenibut use can further increase these risks, highlighting the importance of adhering to recommended dosages, cycling phenibut use, monitoring for side effects, and consulting a healthcare professional before starting or modifying phenibut use.

Safer, natural alternatives to phenibut, such as L-theanine, ashwagandha, Bacopa Monnieri, valerian root, and passionflower, may provide similar benefits without the associated risks. By considering these alternatives and consulting with a healthcare professional, individuals seeking relief from anxiety or cognitive enhancement can make informed decisions about the safest and most effective treatment options.

Please note that phenibut is not approved for medical use in many countries, including the United States, and is often sold as a dietary supplement. As such, the quality and purity of phenibut products can vary significantly, further emphasizing the importance of caution and consultation with a healthcare professional before use. Additionally, the information provided in this article should not replace professional medical advice, diagnosis, or treatment. Always seek the guidance of a healthcare professional before starting any new treatment or supplement, including phenibut.

References

Akhondzadeh, S., Naghavi, H. R., Vazirian, M., Shayeganpour, A., Rashidi, H., & Khani, M. (2001). Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics, 26(5), 363-367.

Calabrese, C., Gregory, W. L., Leo, M., Kraemer, D., Bone, K., & Oken, B. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 14(6), 707-713.

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255-262.

Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: A randomized controlled trial. Nutrients, 11(10), 2362.

Houghton, P. J. (1999). The scientific basis for the reputed activity of Valerian. Journal of Pharmacy and Pharmacology, 51(5), 505-512.

Lapin, I. (2001). Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug. CNS Drug Reviews, 7(4), 471-481.

Owen, D. R., Wood, D. M., Archer, J. R., & Dargan, P. I. (2016). Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity. Drug and Alcohol Review, 35(5), 591-596.

Samokhvalov, A. V., Paton-Gay, C. L., Balchand, K., & Rehm, J. (2013). Phenibut dependence. BMJ Case Reports, 2013, bcr2012008381.

Phenibut is a central nervous system (CNS) depressant developed in the 1960s

Phenibut, a popular anxiolytic and nootropic supplement, has gained attention for its

About the Author Chris Fraighten


Chris Fraighten is a leading biomedical researcher and currently the lead author of the Epimodels blog. He holds qualifications in chemistry, biology and is highly experienced in the fields of quantitative modelling and epidemiology. He brings this wealth of knowledge and experience to the Epimodels blog to bring you insightful, informative and interesting content on the latest advances in the space.