Within-host viral dynamics of dengue serotype 1 infection.

TitleWithin-host viral dynamics of dengue serotype 1 infection.
Publication TypeJournal Article
Year of Publication2014
AuthorsClapham HE, Tricou V, Chau NVan Vinh, Simmons CP, Ferguson NM
JournalJ R Soc Interface
Volume11
Issue96
Date Published2014 Jul 6
ISSN1742-5662
Abstract

Dengue, the most common mosquito-borne viral infection of humans, is endemic across much of the world, including much of tropical Asia and is increasing in its geographical range. Here, we present a mathematical model of dengue virus dynamics within infected individuals, detailing the interaction between virus and a simple immune response. We fit this model to measurements of plasma viral titre from cases of primary and secondary DENV 1 infection in Vietnam. We show that variation in model parameters governing the immune response is sufficient to create the observed variation in virus dynamics between individuals. Estimating model parameter values, we find parameter differences between primary and secondary cases consistent with the theory of antibody-dependent enhancement (namely enhanced rates of viral entry to target cells in secondary cases). Finally, we use our model to examine the potential impact of an antiviral drug on the within-host dynamics of dengue. We conclude that the impact of antiviral therapy on virus dynamics is likely to be limited if therapy is only started at the onset of symptoms, owing to the typically late stage of viral pathogenesis reached by the time symptoms are manifested and thus treatment is started.

DOI10.1098/rsif.2014.0094
Alternate JournalJ R Soc Interface
PubMed ID24829280
PubMed Central IDPMC4032531
Grant ListU54 GM088491 / GM / NIGMS NIH HHS / United States
/ / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom
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