Viral kinetics of primary dengue virus infection in non-human primates: a systematic review and individual pooled analysis.

TitleViral kinetics of primary dengue virus infection in non-human primates: a systematic review and individual pooled analysis.
Publication TypeJournal Article
Year of Publication2014
AuthorsAlthouse BM, Durbin AP, Hanley KA, Halstead SB, Weaver SC, Cummings DAT
JournalVirology
Volume452-453
Pagination237-46
Date Published2014 Mar
ISSN1096-0341
KeywordsAnimals, Dengue, Dengue Virus, Humans, Kinetics, Macaca mulatta, Viremia
Abstract

Viremia kinetics directly influence the clinical course and transmission dynamics of DENV, but many aspects of viral dynamics remain unknown. Non-human primates (NHP) have been used as a model system for DENV infection for decades. Here, we identify papers with experimentally-infected NHP and estimate the time to- and duration of viremia as well as estimate associations between these and serotype, inoculating dose, viremia assay, and species of NHP. We estimate the time to viremia in rhesus macaques to range from 2.63 to 3.32 days for DENV-2 and -1 and the duration to range from 3.13 to 5.13 days for DENV-4 and -2. We find no differences between non-human primates for time to viremia or duration, and a significant negative relationship between inoculating dose and duration of viremia. These results aid in understanding the transmission dynamics of sylvatic DENV non-human primates, an issue of growing importance as dengue vaccines become available.

DOI10.1016/j.virol.2014.01.015
Alternate JournalVirology
PubMed ID24606701
Grant List1U54GM088491-0109 / GM / NIGMS NIH HHS / United States
AI069145 / AI / NIAID NIH HHS / United States
R01 AI069145 / AI / NIAID NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
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