Menstrual cycle and detectable human papillomavirus in reproductive-age women: a time series study.

TitleMenstrual cycle and detectable human papillomavirus in reproductive-age women: a time series study.
Publication TypeJournal Article
Year of Publication2013
AuthorsLiu S-H, Brotman RM, Zenilman JM, Gravitt PE, Cummings DAT
JournalJ Infect Dis
Volume208
Issue9
Pagination1404-15
Date Published2013 Nov 1
ISSN1537-6613
KeywordsAdult, Female, Humans, Longitudinal Studies, Menstrual Cycle, Middle Aged, Papillomavirus Infections, Prevalence, Sexual Behavior, Vaginosis, Bacterial
Abstract

BACKGROUND: Current evidence on the relationship between human papillomavirus (HPV) DNA detection and menstrual cycle has been inconsistent.METHODS: We included 21 nonoral contraceptive pill (non-OCP) users who self-collected vaginal samples twice per week for 16 weeks. We explored whether variable detection of HPV DNA exhibited cyclic or other structured temporal patterns. We also evaluated relationships between serial HPV prevalence, sexual behavior, and suspected bacterial vaginosis (BV) as defined by Nugent Gram stain score ≥7.RESULTS: During follow-up, any-type HPV prevalence varied between 61.1% and 85.0%. Although not statistically significant, we observed a maximum autocorrelation in serial HPV prevalence lagging 14 days (correlation coefficient [ρ], -0.24). Any-type HPV detection had a periodic behavior, generally repeating every 28.0 days (bootstrapped interquartile range, 22.4-28.0) and peaking around the ovulation time (adjusted odds ratio, 1.96; 95% confidence interval [CI], 1.06-3.62) as compared to menstruation. We also showed that an increase in any-type HPV prevalence preceded the beginning of a menstrual cycle by 9-12 days. There was no evidence of relationships between HPV prevalence and sexual activity or Nugent score.CONCLUSIONS: Serially detected any-type HPV DNA showed a periodic behavior and was likely to peak in the periovulatory phase among non-OCP users.

DOI10.1093/infdis/jit337
Alternate JournalJ. Infect. Dis.
PubMed ID23885113
PubMed Central IDPMC3789568
Grant ListK01 AI080974 / AI / NIAID NIH HHS / United States
K01 AI080974 / AI / NIAID NIH HHS / United States
R03 AI061131 / AI / NIAID NIH HHS / United States
R03 AI061131 / AI / NIAID NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
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