Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England.

TitleIncreased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England.
Publication TypeJournal Article
Year of Publication2013
AuthorsDorigatti I, Cauchemez S, Ferguson NM
JournalProc Natl Acad Sci U S A
Volume110
Issue33
Pagination13422-7
Date Published2013 Aug 13
ISSN1091-6490
KeywordsAdult, Bayes Theorem, England, Epidemiological Monitoring, Evolution, Molecular, History, 21st Century, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Models, Theoretical, Pandemics
Abstract

In the 2009 H1N1 pandemic, the United Kingdom experienced two waves of infection, the first in the late spring and the second in the autumn. Given the low level of susceptibility to the pandemic virus expected to be remaining in the population after the second wave, it was a surprise that a substantial third epidemic occurred in the UK population between November 2010 and February 2011, despite no evidence for any significant antigenic evolution of the pandemic virus. Here, we use a mathematical model of influenza transmission embedded within a Bayesian synthesis inferential framework to jointly analyze syndromic, virological, and serological surveillance data collected in England in 2009-2011 and thereby assess epidemiological mechanisms which might have generated the third wave. We find that substantially increased transmissibility of the H1N1pdm09 virus is required to reproduce the third wave, suggesting that the virus evolved and increased fitness in the human host by the end of 2010, or that the very cold weather experienced in the United Kingdom at that time enhanced transmission rates. We also find some evidence that the preexisting heterologous immunity which reduced attack rates in adults during 2009 had substantially decayed by the winter of 2010, thus increasing the susceptibility of the adult population to infection. Finally, our analysis suggests that a pandemic vaccination campaign targeting adults and school-age children could have mitigated or prevented the third wave even at moderate levels of coverage.

DOI10.1073/pnas.1303117110
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID23882078
PubMed Central IDPMC3746905
Grant ListU54 GM088491 / GM / NIGMS NIH HHS / United States
/ / Medical Research Council / United Kingdom
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