Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity.

TitleInteractions between serotypes of dengue highlight epidemiological impact of cross-immunity.
Publication TypeJournal Article
Year of Publication2013
AuthorsReich NG, Shrestha S, King AA, Rohani P, Lessler J, Kalayanarooj S, Yoon I-K, Gibbons RV, Burke DS, Cummings DAT
JournalJ R Soc Interface
Date Published2013 Sep 6
KeywordsAnimals, Cross Protection, Cross Reactions, Culicidae, Dengue, Dengue Virus, Female, Humans, Immunologic Memory, Male, Models, Immunological, Retrospective Studies, Thailand

Dengue, a mosquito-borne virus of humans, infects over 50 million people annually. Infection with any of the four dengue serotypes induces protective immunity to that serotype, but does not confer long-term protection against infection by other serotypes. The immunological interactions between serotypes are of central importance in understanding epidemiological dynamics and anticipating the impact of dengue vaccines. We analysed a 38-year time series with 12 197 serotyped dengue infections from a hospital in Bangkok, Thailand. Using novel mechanistic models to represent different hypothesized immune interactions between serotypes, we found strong evidence that infection with dengue provides substantial short-term cross-protection against other serotypes (approx. 1-3 years). This is the first quantitative evidence that short-term cross-protection exists since human experimental infection studies performed in the 1950s. These findings will impact strategies for designing dengue vaccine studies, future multi-strain modelling efforts, and our understanding of evolutionary pressures in multi-strain disease systems.

Alternate JournalJ R Soc Interface
PubMed ID23825116
PubMed Central IDPMC3730691
Grant List1U54GM088491-0109 / GM / NIGMS NIH HHS / United States
R01 GM090204 / GM / NIGMS NIH HHS / United States
R01GM090204 / GM / NIGMS NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
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