Transmission scenarios for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and how to tell them apart.

TitleTransmission scenarios for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and how to tell them apart.
Publication TypeJournal Article
Year of Publication2013
AuthorsCauchemez S, Van Kerkhove MD, Riley S, Donnelly CA, Fraser C, Ferguson NM
JournalEuro Surveill
Date Published2013
KeywordsCoronavirus, Coronavirus Infections, Disease Reservoirs, Epidemics, Humans, Respiratory Tract Infections, Risk Assessment

Detection of human cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection internationally is a global public health concern. Rigorous risk assessment is particularly challenging in a context where surveillance may be subject to under-ascertainment and a selection bias towards more severe cases. We would like to assess whether the virus is capable of causing widespread human epidemics, and whether self-sustaining transmission is already under way. Here we review possible transmission scenarios for MERS-CoV and their implications for risk assessment and control. We discuss how existing data, future investigations and analyses may help in reducing uncertainty and refining the public health risk assessment and present analytical approaches that allow robust assessment of epidemiological characteristics, even from partial and biased surveillance data. Finally, we urge that adequate data be collected on future cases to permit rigorous assessment of the transmission characteristics and severity of MERS-CoV, and the public health threat it may pose. Going beyond minimal case reporting, open international collaboration, under the guidance of the World Health Organization and the International Health Regulations, will impact on how this potential epidemic unfolds and prospects for control.

Alternate JournalEuro Surveill.
PubMed ID23787162
PubMed Central IDPMC4088931
Grant ListU54 GM088491 / GM / NIGMS NIH HHS / United States
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