Breaking the symmetry: immune enhancement increases persistence of dengue viruses in the presence of asymmetric transmission rates.

TitleBreaking the symmetry: immune enhancement increases persistence of dengue viruses in the presence of asymmetric transmission rates.
Publication TypeJournal Article
Year of Publication2013
AuthorsMier-y-Teran-Romero L, Schwartz IB, Cummings DAT
JournalJ Theor Biol
Volume332
Pagination203-10
Date Published2013 Sep 7
ISSN1095-8541
KeywordsDengue, Dengue Vaccines, Dengue Virus, Humans, Models, Immunological
Abstract

The dengue viruses exist as four antigenically distinct serotypes. These four serotypes co-circulate and interact with each other through multiple immune-mediated mechanisms. Though the majority of previous efforts to understand the transmission dynamics of dengue have assumed identical characteristics for these four serotypes, empirical data suggests that they differ from one another in important ways. Here, we examine dynamics and persistence in models that do not assume symmetry between the dengue viruses. We find that for serotype transmission rates that are only slightly asymmetric, increased transmissibility of secondary infections through immune enhancement increases the persistence of all dengue viruses in opposition to findings in symmetric models. We identify an optimal magnitude of immune enhancement that maximizes the probability of persistence of all four serotypes. In contrast to other pathogen systems where heterogeneity between serotypes in transmissibility facilitates competitive exclusion (Bremmermann and Thieme, 1989), here we find that in the presence of Antibody Dependent Enhancement (ADE) heterogeneity can increase the persistence of multiple serotypes of dengue.

DOI10.1016/j.jtbi.2013.04.036
Alternate JournalJ. Theor. Biol.
PubMed ID23665358
PubMed Central IDPMC3782297
Grant List1U54GM088491-0109 / GM / NIGMS NIH HHS / United States
R01 GM090204 / GM / NIGMS NIH HHS / United States
R01GM090204 / GM / NIGMS NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
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