The potential economic value of a Staphylococcus aureus vaccine among hemodialysis patients.

TitleThe potential economic value of a Staphylococcus aureus vaccine among hemodialysis patients.
Publication TypeJournal Article
Year of Publication2012
AuthorsSong Y, H Y Tai J, Bartsch SM, Zimmerman RK, Muder RR, Lee BY
JournalVaccine
Volume30
Issue24
Pagination3675-82
Date Published2012 May 21
ISSN1873-2518
KeywordsAged, Aged, 80 and over, Costs and Cost Analysis, Female, Humans, Male, Middle Aged, Models, Statistical, Renal Dialysis, Staphylococcal Infections, Staphylococcal Vaccines, Staphylococcus aureus
Abstract

Staphylococcus aureus infections are a substantial problem for hemodialysis patients. Several vaccine candidates are currently under development, with hemodialysis patients being one possible target population. To determine the potential economic value of an S. aureus vaccine among hemodialysis patients, we developed a Markov decision analytic computer simulation model. When S. aureus colonization prevalence was 1%, the incremental cost-effectiveness ratio (ICER) of vaccination was ≤$25,217/quality-adjusted life year (QALY). Vaccination became more cost-effective as colonization prevalence, vaccine efficacy, or vaccine protection duration increased or vaccine cost decreased. Even at 10% colonization prevalence, a 25% efficacious vaccine costing $100 prevented 29 infections, 21 infection-related hospitalizations, and 9 inpatient deaths per 1000 vaccinated HD patients. Our results suggest that an S. aureus vaccine would be cost-effective (i.e., ICERs ≤ $50,000/QALY) among hemodialysis patients over a wide range of S. aureus prevalence, vaccine costs and efficacies, and vaccine protection durations and delineate potential target parameters for such a vaccine.

DOI10.1016/j.vaccine.2012.03.031
Alternate JournalVaccine
PubMed ID22464963
PubMed Central IDPMC3371356
Grant List5U54GM088491-02 / GM / NIGMS NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
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