Multiannual patterns of influenza A transmission in Chinese live bird market systems.

TitleMultiannual patterns of influenza A transmission in Chinese live bird market systems.
Publication TypeJournal Article
Year of Publication2013
AuthorsPepin KM, Wang J, Webb CT, Smith GJD, Poss M, Hudson PJ, Hong W, Zhu H, Riley S, Guan Y
JournalInfluenza Other Respir Viruses
Date Published2013 Jan
KeywordsAnimals, Chickens, China, Disease Outbreaks, Ducks, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus, Host Specificity, Humans, Incidence, Influenza A virus, Influenza in Birds, Poultry, Poultry Diseases, Prevalence, Species Specificity

BACKGROUND: Avian influenza viruses (AIV) cause huge economic losses in poultry industries and pose a substantial threat to human health. However, predicting AIV epizootics and emergence in humans is confounded by insufficient empirical data on the ecology and dynamics of AIV in poultry systems. To address this gap, we quantified incidence patterns for 13 hemagglutinin subtypes of AIV using 6 years of surveillance data that were collected from ten different species of poultry and three different types of poultry holdings (contexts) - retail, wholesale, or farms.METHODS: We collected 42 646 samples in Shantou, China between 2000 and 2006. We screened samples for hemagglutinin subtypes 1-13 of AIV and Avian Paramyxovirus-type-1 (APMV-1) using monospecific antisera in hemagglutination inhibition tests. We analyzed the data to determine seasonality patterns, subtype-host, and subtype-subtype interactions as well as subtype bias in incidence in different contexts.RESULTS: H3, H6, H9, and APMV-1 were the most prevalent. No significant seasonality was found when all subtypes were considered together. For most AIV subtypes and APMV-1, there was subtype specificity for host, context, and coinfection partner. H5 showed the most generalized host usage pattern, followed by H9 and H6.CONCLUSION: Subtype-specific patterns because of host, context, and other subtypes suggest that risk assessments that exclude these details are likely inaccurate. Surveillance should include longitudinal sampling of multiple host species in multiple contexts. Quantitative models of control strategies must consider multiple subtypes, hosts, and source contexts to assess the effectiveness of interventions.

Alternate JournalInfluenza Other Respir Viruses
PubMed ID22458429
PubMed Central IDPMC4061500
Grant ListR01 TW008246 / TW / FIC NIH HHS / United States
R01 TW008246-01 / TW / FIC NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
/ / Wellcome Trust / United Kingdom
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