Serial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendations.

TitleSerial intervals and the temporal distribution of secondary infections within households of 2009 pandemic influenza A (H1N1): implications for influenza control recommendations.
Publication TypeJournal Article
Year of Publication2011
AuthorsDonnelly CA, Finelli L, Cauchemez S, Olsen SJ, Doshi S, Jackson ML, Kennedy ED, Kamimoto L, Marchbanks TL, Morgan OW, Patel M, Swerdlow DL, Ferguson NM
Corporate AuthorspH1N1 Household Investigations Working Group
JournalClin Infect Dis
Volume52 Suppl 1
PaginationS123-30
Date Published2011 Jan 1
ISSN1537-6591
KeywordsAdolescent, Child, Family Characteristics, Family Health, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Male, Time Factors, United States
Abstract

A critical issue during the 2009 influenza A (H1N1) pandemic was determining the appropriate duration of time individuals with influenza-like illness (ILI) should remain isolated to reduce onward transmission while limiting societal disruption. Ideally this is based on knowledge of the relative infectiousness of ill individuals at each point during the course of the infection. Data on 261 clinically apparent pH1N1 infector-infectee pairs in households, from 7 epidemiological studies conducted in the United States early in 2009, were analyzed to estimate the distribution of times from symptom onset in an infector to symptom onset in the household contacts they infect (mean, 2.9 days, not correcting for tertiary transmission). Only 5% of transmission events were estimated to take place >3 days after the onset of clinical symptoms among those ill with pH1N1 virus. These results will inform future recommendations on duration of isolation of individuals with ILI.

DOI10.1093/cid/ciq028
Alternate JournalClin. Infect. Dis.
PubMed ID21342883
PubMed Central IDPMC3106264
Grant List1U54GM088491-01 / GM / NIGMS NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
U60/CCU007277 / / PHS HHS / United States
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