Single versus multi-dose vaccine vials: an economic computational model.

TitleSingle versus multi-dose vaccine vials: an economic computational model.
Publication TypeJournal Article
Year of Publication2010
AuthorsLee BY, Norman BA, Assi T-M, Chen S-I, Bailey RR, Rajgopal J, Brown ST, Wiringa AE, Burke DS
JournalVaccine
Volume28
Issue32
Pagination5292-300
Date Published2010 Jul 19
ISSN1873-2518
KeywordsCosts and Cost Analysis, Drug Storage, Humans, Medical Waste Disposal, Models, Economic, Vaccination, Vaccines, Vaccines, Combined
Abstract

Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial).

DOI10.1016/j.vaccine.2010.05.048
Alternate JournalVaccine
PubMed ID20566395
PubMed Central IDPMC2919154
Grant List1U54GM088491-0109 / GM / NIGMS NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
U54 GM088491-01 / GM / NIGMS NIH HHS / United States
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