The potential value of Clostridium difficile vaccine: an economic computer simulation model.

TitleThe potential value of Clostridium difficile vaccine: an economic computer simulation model.
Publication TypeJournal Article
Year of Publication2010
AuthorsLee BY, Popovich MJ, Tian Y, Bailey RR, Ufberg PJ, Wiringa AE, Muder RR
JournalVaccine
Volume28
Issue32
Pagination5245-53
Date Published2010 Jul 19
ISSN1873-2518
KeywordsBacterial Vaccines, Clostridium difficile, Computer Simulation, Cost-Benefit Analysis, Enterocolitis, Pseudomembranous, Humans, Models, Economic, Monte Carlo Method, Recurrence, Risk Factors
Abstract

Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease.

DOI10.1016/j.vaccine.2010.05.062
Alternate JournalVaccine
PubMed ID20541582
PubMed Central IDPMC2908196
Grant List1U54GM088491-0109 / GM / NIGMS NIH HHS / United States
U54 GM088491 / GM / NIGMS NIH HHS / United States
U54 GM088491-01 / GM / NIGMS NIH HHS / United States
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